The FcRγ Chain Is Not Essential for Induction of Experimental Allergic Encephalomyelitis (EAE) or Anti-Myelin Antibody-Mediated Exacerbation of EAE
نویسندگان
چکیده
منابع مشابه
The FcRgamma chain is not essential for induction of experimental allergic encephalomyelitis (EAE) or anti-myelin antibody-mediated exacerbation of EAE.
Macrophages are considered essential mediators in multiple sclerosis (MS) pathogenesis, presumably through myelin phagocytosis and release of inflammatory mediators. Macrophages and microglia express activating Fcgamma receptors (FcgammaRI and FcgammaRIII), which depend on the FcRgamma chain for surface expression and signaling. In MS lesions, crosslinking of FcgammaR by immunoglobulins (IgG) d...
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Thank you for the submission of your manuscript "Inhibition of the immunoproteasome strongly ameliorates experimental autoimmune encephalomyelitis (EAE)". We have now heard back from the three referees whom we asked to evaluate your manuscript. As you will see, the referees acknowledge that the overall topic of the manuscript is potentially interesting. However, they also raise significant conc...
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ژورنال
عنوان ژورنال: Journal of Neuropathology & Experimental Neurology
سال: 2005
ISSN: 0022-3069,1554-6578
DOI: 10.1093/jnen/64.4.304